RET-IN-3

• CAT Number: I015279
• CAS Number: 2414374-53-9
• Molecular Formula: C18H21N5O2
• Molecular Weight: 339.39
• Purity: ≥95%
• Synonyms: N-[3-(1,3-benzodioxol-5-yl)pyrazolo[1,5-a]pyrimidin-5-yl]-N’,N’-dimethylpropane-1,3-diamine
• IUPAC Name: N-[3-(1,3-benzodioxol-5-yl)pyrazolo[1,5-a]pyrimidin-5-yl]-N',N'-dimethylpropane-1,3-diamine
• InChI: InChI=1S/C18H21N5O2/c1-22(2)8-3-7-19-17-6-9-23-18(21-17)14(11-20-23)13-4-5-15-16(10-13)25-12-24-15/h4-6,9-11H,3,7-8,12H2,1-2H3,(H,19,21)
• InChIKey: DQYRQFLRDJTHQM-UHFFFAOYSA-N
• SMILES: CN(C)CCCNC1=NC2=C(C=NN2C=C1)C3=CC4=C(C=C3)OCO4

RET-IN-3（Cat No.:I015279）is a selective small-molecule inhibitor of the RET receptor tyrosine kinase, a key driver in multiple cancers including medullary thyroid carcinoma, non-small cell lung cancer, and other RET-altered malignancies. By blocking RET phosphorylation and downstream signaling, RET-IN-3 suppresses pathways involved in tumor cell proliferation, survival, and migration. This compound is a valuable research tool for investigating RET-driven oncogenesis and testing targeted therapeutic strategies. Its selectivity and potency make it useful in chemical biology, preclinical cancer studies, and the development of precision oncology treatments.