Resibufagin

For research use only. Not for therapeutic Use.

  • CAT Number: I044941
  • CAS Number: 20987-24-0
  • Molecular Formula: C24H30O5
  • Molecular Weight: 398.49
  • Purity: ≥95%
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Resibufagin(Cat No.:I044941)is a bioactive bufadienolide compound isolated from toad venom, particularly from species like Bufo bufo gargarizans, traditionally used in Chinese medicine. It belongs to the steroidal cardiac glycoside family and exhibits potent pharmacological activities, including cardiotonic, anticancer, and anti-inflammatory effects. Resibufagin exerts its action by inhibiting Na⁺/K⁺-ATPase, leading to increased intracellular calcium, which enhances cardiac contractility. It has also been shown to induce apoptosis and inhibit proliferation in various cancer cell lines. Due to its strong bioactivity, resibufagin is being explored for therapeutic applications under tightly controlled conditions.


CAS Number 20987-24-0
Synonyms

(1R,2S,4R,6R,7R,10S,11R,14S,16R)-14-hydroxy-7-methyl-6-(6-oxopyran-3-yl)-3-oxapentacyclo[8.8.0.02,4.02,7.011,16]octadecane-11-carbaldehyde

Molecular Formula C24H30O5
Purity ≥95%
IUPAC Name (1R,2S,4R,7R,10S,11R,14S,16R)-14-hydroxy-7-methyl-6-(6-oxopyran-3-yl)-3-oxapentacyclo[8.8.0.02,4.02,7.011,16]octadecane-11-carbaldehyde
InChI InChI=1S/C24H30O5/c1-22-8-7-17-18(4-3-15-10-16(26)6-9-23(15,17)13-25)24(22)20(29-24)11-19(22)14-2-5-21(27)28-12-14/h2,5,12-13,15-20,26H,3-4,6-11H2,1H3/t15-,16+,17+,18-,19?,20-,22-,23-,24-/m1/s1
InChIKey LFLJTMIVTFTLOA-UIZOPSFESA-N
SMILES C[C@]12CC[C@H]3[C@H]([C@@]14[C@H](O4)CC2C5=COC(=O)C=C5)CC[C@H]6[C@@]3(CC[C@@H](C6)O)C=O
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