rel-Zotatifin

• CAT Number: I045615
• CAS Number: 2098191-54-7
• Molecular Formula: C28H29N3O5
• Molecular Weight: 487.56
• Purity: ≥95%

rel-Zotatifin (Cat No.: I045615) is a selective, reversible inhibitor of the eukaryotic translation initiation factor 4A (eIF4A), an RNA helicase critical for cap-dependent mRNA translation. By blocking eIF4A activity, rel-Zotatifin suppresses the synthesis of oncogenic and survival-promoting proteins, including those involved in cancer progression and antiviral responses. It has been investigated in preclinical and clinical studies for the treatment of solid tumors and viral infections. Rel-Zotatifin is a valuable tool for exploring translational control, cancer therapeutics, and host-targeted antiviral strategies.

Reference

[1]. Peggy A. Thompson, et al. Preclinical Evaluation of eFT226, a Novel, Potent and Selective eIF4A Inhibitor with Anti-tumor Activity in B-cell Malignancies.

[2]. Gordon DE, et al. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.Nature. 2020 Apr 30.
[Content Brief]