For research use only. Not for therapeutic Use.
(rel)-AR234960(CAT: I016658) is the active relative configuration of AR234960, a non-peptide agonist of the MAS receptor, a G protein-coupled receptor (GPCR) involved in cardiovascular signaling. AR234960 has been shown to increase both mRNA and protein expression of connective tissue growth factor (CTGF) through ERK1/2 signaling in HEK293-MAS cells and adult human cardiac fibroblasts. By modulating MAS receptor activity, (rel)-AR234960 provides a valuable tool for investigating GPCR-mediated pathways in cardiovascular research, fibrosis, and tissue remodeling. It supports studies into novel therapeutic strategies targeting MAS signaling for cardiovascular disease and related pathological conditions.
| CAS Number | 1408311-94-3 |
| Synonyms | 1-[[(3R,4R)-4-(3-fluorophenyl)-1-(2-methoxy-4-nitrophenyl)sulfonylpyrrolidin-3-yl]methyl]-4-pyridin-2-ylpiperazine |
| Molecular Formula | C27H30FN5O5S |
| Purity | ≥95% |
| IUPAC Name | 1-[[(3R,4R)-4-(3-fluorophenyl)-1-(2-methoxy-4-nitrophenyl)sulfonylpyrrolidin-3-yl]methyl]-4-pyridin-2-ylpiperazine |
| InChI | InChI=1S/C27H30FN5O5S/c1-38-25-16-23(33(34)35)8-9-26(25)39(36,37)32-18-21(24(19-32)20-5-4-6-22(28)15-20)17-30-11-13-31(14-12-30)27-7-2-3-10-29-27/h2-10,15-16,21,24H,11-14,17-19H2,1H3/t21-,24+/m1/s1 |
| InChIKey | TUSCHIFEASZBBF-QPPBQGQZSA-N |
| SMILES | COC1=C(C=CC(=C1)[N+](=O)[O-])S(=O)(=O)N2CC(C(C2)C3=CC(=CC=C3)F)CN4CCN(CC4)C5=CC=CC=N5 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
