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RE 201

RE 201

  • CAT Number: R018917
  • CAS Number: 254740-64-2
  • Molecular Formula: C₃₂H₄₀N₄O₅S
  • Molecular Weight: 592.75
  • Purity: ≥95%
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Sparsentan, also known as RE-021, PS433540 and DARA-a, is a Dual angiotensin II and endothelin A receptor antagonist. Retrophin intends to develop RE-021 for orphan indications of severe kidney diseases including Focal Segmental Glomerulosclerosis (FSGS) as well as conduct proof-of-concept studies in resistant hypertension and diabetic nephropathy. RE-021, with its unique dual blockade of angiotensin and endothelin receptors, is expected to provide meaningful clinical benefits in mitigating proteinuria in indications where there are no approved therapies.

Catalog Number R018917
CAS Number 254740-64-2
Synonyms

4’-((2-Butyl-4-oxo-1,3-diazaspiro[4.4]non-2-en-1-yl)methyl)-N-(4,5-dimethylisoxazol-3-yl)-2’-(ethoxymethyl)-[1,1’-biphenyl]-2-sulfonamide

Molecular Formula

C₃₂H₄₀N₄O₅S

Purity 95%
Target Dual angiotensin II and endothelin A receptor antagonist
Storage Store at -20°C
Reference

</br>1:SU-E-T-201: Safety-Focused Customization of Treatment Plan Documentation. Schubert L, Westerly D, Stuhr K, Miften M.Med Phys. 2012 Jun;39(6Part12):3749. doi: 10.1118/1.4735261. PMID: 28517828 </br>2:Re: Scott P. Kelly, Philip S. Rosenberg, William F. Anderson, et al. Trends in the Incidence of Fatal Prostate Cancer in the United States by Race. Eur Urol 2017;71:195-201. Brookman-May SD, May M, Lebentrau S, Klotz T.Eur Urol. 2017 May;71(5):e145-e146. doi: 10.1016/j.eururo.2016.10.024. Epub 2016 Oct 27. No abstract available. PMID: 28008855 </br>3:Clinical significance of right ventricular activity on treadmill thallium-201 myocardial single-photon emission computerized tomography using cadmium-zinc-telluride cameras. Ko KY, Wu YW, Liu CJ, Cheng MF, Yen RF, Tzen KY.Nucl Med Commun. 2016 Jun;37(6):650-7. doi: 10.1097/MNM.0000000000000494. PMID: 27110956 </br>4:Reply from Authors re: Tahlita C.M. Zuiverloon, Ellen C. Zwarthoff. Predicting Response to Intravesical Bacillus Calmette-Guérin Immunotherapy: Are We Moving Forward? Eur Urol 2016;69:201-2: The Goal: Individualized Bacillus Calmette-Guérin Therapy. Kamat AM, Urbauer DL.Eur Urol. 2016 Feb;69(2):203. doi: 10.1016/j.eururo.2015.07.031. Epub 2015 Aug 7. No abstract available. PMID: 26260001 </br>5:Re: activity and safety of ODM-201 in patients with progressive metastatic castration-resistant prostate cancer (ARADES): an open-label phase 1 dose-escalation and randomised phase 2 dose expansion trial. Bjartell A.Eur Urol. 2015 Feb;67(2):348-9. doi: 10.1016/j.eururo.2014.11.019. No abstract available. PMID: 25760250 </br>6:Re: analysis of intradiscal cement leakage during percutaneous vertebroplasty: multivariate study of risk factors emphasizing preoperative MR finding. J Neuroraidol 2014;41(3):195-201. Lee KH, Yoo DS.J Neuroradiol. 2015 Apr;42(2):130-1. doi: 10.1016/j.neurad.2015.01.001. Epub 2015 Feb 13. No abstract available. PMID: 25682919 Free Article</br>7:Re: Yang et al.: Two-stage repair with long channel technique for primary severe hypospadias (Urology 2014;84:198-201). Papeš D, Bracka A.Urology. 2014 Oct;84(4):985-6. doi: 10.1016/j.urology.2014.06.048. No abstract available. PMID: 25260459 </br>8:Re: 150 minutes of vigorous physical activity per week predicts survival and successful ageing: a population-based 11-year longitudinal study of 12 201 older Australian men. Seftel AD.J Urol. 2014 May;191(5):1351-2. doi: 10.1016/j.juro.2014.02.074. Epub 2014 Feb 22. No abstract available. PMID: 24745514 </br>9:Commentary on /Toxicity after external beam radiotherapy for prostate cancer: an analysis of late morbidity in men with diabetes mellitus./ Kalakota K, Liauw SL, Department of Radiation Oncology, Northwestern Memorial Hospital, Chicago, IL.: Urology 2013;81(6):1196-201. doi: 10.1016/j.urology.2013.01.047. [Epub 2013 Mar 26]. Gottschalk A.Urol Oncol. 2014 Apr;32(3):374. doi: 10.1016/j.urolonc.2013.09.021. PMID: 24679464 </br>10:p-Tertbutylcalix[4]arene nanoemulsion: preparation, characterization and comparative evaluation of its decontamination efficacy against Technetium-99m, Iodine-131 and Thallium-201. Rana S, Sharma N, Ojha H, Shivkumar HG, Sultana S, Sharma RK.Colloids Surf B Biointerfaces. 2014 May 1;117:114-21. doi: 10.1016/j.colsurfb.2014.02.001. Epub 2014 Feb 21. PMID: 24632037

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