RE 201 - CAS 254740-64-2

Sparsentan, also known as RE-021, PS433540 and DARA-a, is a Dual angiotensin II and endothelin A receptor antagonist. Retrophin intends to develop RE-021 for orphan indications of severe kidney diseases including Focal Segmental Glomerulosclerosis (FSGS) as well as conduct proof-of-concept studies in resistant hypertension and diabetic nephropathy. RE-021, with its unique dual blockade of angiotensin and endothelin receptors, is expected to provide meaningful clinical benefits in mitigating proteinuria in indications where there are no approved therapies.

Catalog Number: R018917

CAS Number: 254740-64-2

PubChem Substance ID:355036018

Molecular Formula: C₃₂H₄₀N₄O₅S

Molecular Weight:592.75

Purity: ≥95%

* For research use only. Not for human or veterinary use.

Synonym

• Synonyms: 4’-((2-Butyl-4-oxo-1,3-diazaspiro[4.4]non-2-en-1-yl)methyl)-N-(4,5-dimethylisoxazol-3-yl)-2’-(ethoxymethyl)-[1,1’-biphenyl]-2-sulfonamide

Property

• Molecular Formula: C₃₂H₄₀N₄O₅S
• Molecular Weight: 592.75
• Target: Dual angiotensin II and endothelin A receptor antagonist
• Purity: ≥95%
• Storage: Store at -20°C