RAS inhibitor Abd-7

• CAT Number: I045512
• CAS Number: 2351843-48-4
• Molecular Formula: C23H25N3O3
• Molecular Weight: 391.46
• Purity: ≥95%
• Synonyms: 6-(2,3-dihydro-1,4-benzodioxin-5-yl)-N-[4-[(dimethylamino)methyl]phenyl]-2-methoxypyridin-3-amine
• InChI: InChI=1S/C23H25N3O3/c1-26(2)15-16-7-9-17(10-8-16)24-20-12-11-19(25-23(20)27-3)18-5-4-6-21-22(18)29-14-13-28-21/h4-12,24H,13-15H2,1-3H3
• InChIKey: MJHHFDJNRRCUOB-UHFFFAOYSA-N
• SMILES: CN(C)CC1=CC=C(C=C1)NC2=C(N=C(C=C2)C3=C4C(=CC=C3)OCCO4)OC

RAS inhibitor Abd-7 (Cat No.: I045512) is a synthetic small molecule designed to block oncogenic RAS signaling, a critical driver of uncontrolled cell proliferation in many cancers. By disrupting RAS activation and downstream MAPK/ERK pathways, Abd-7 suppresses tumor cell growth and survival. Researchers use Abd-7 as a chemical probe to study RAS-dependent oncogenesis, signal transduction, and drug resistance mechanisms. Its activity provides a valuable tool for exploring therapeutic strategies targeting RAS-driven cancers, including pancreatic, colorectal, and lung malignancies where RAS mutations are prevalent.

Reference

[1]. Quevedo CE, et al. Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment. Nat Commun. 2018;9(1):3169. Published 2018 Aug 9.
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