Raphin1 acetate (Cat.No:I018135) is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B). Raphin1 acetate binds strongly to the R15B-PP1c holophosphatase (Kd=33 nM), and shows ~30-fold selective in binding R15B-PP1c over R15A-PP1c. Raphin1 acetate crosses the blood-brain barrier, and reduces organismal and molecular deficits in a mouse model of a protein misfolding disease.
| Catalog Number | I018135 |
| CAS Number | 2242616-04-0 |
| Molecular Formula | C₁₀H₁₂Cl₂N₄O₂ |
| Purity | ≥95% |
| Reference | [1]. Krzyzosiak A, et al. Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B. Cell. 2018 Aug 23;174(5):1216-1228.e19. |
