Raphin1 acetate

  • CAT Number: I018135
  • CAS Number: 2242616-04-0
  • Molecular Formula: C₁₀H₁₂Cl₂N₄O₂
  • Molecular Weight: 291.13
  • Purity: ≥95%
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Raphin1 acetate (Cat.No:I018135) is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B). Raphin1 acetate binds strongly to the R15B-PP1c holophosphatase (Kd=33 nM), and shows ~30-fold selective in binding R15B-PP1c over R15A-PP1c. Raphin1 acetate crosses the blood-brain barrier, and reduces organismal and molecular deficits in a mouse model of a protein misfolding disease.

Catalog Number I018135
CAS Number 2242616-04-0
Molecular Formula

C₁₀H₁₂Cl₂N₄O₂

Purity 95%
Reference

[1]. Krzyzosiak A, et al. Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B. Cell. 2018 Aug 23;174(5):1216-1228.e19.

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