Rapamycin- CAS 53123-88-9

Rapamycin(A000450) is also known as Sirolimus, which is produced by the bacterium Streptomyces hygroscopicus. As a natural macrolide compound, it binds to immunophilin FK-binding protein-12 (FKBP-12) and inhibits the activation of mTOR, resulting in a blockage of T cell activation and proliferation. This product is used in medical research and development and other scientific research fields.

Catalog Number: A000450

CAS Number: 53123-88-9

PubChem Substance ID:355040746

Molecular Formula: C51H79NO13

Molecular Weight:914.19

Purity: ≥95%

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* For research use only. Not for human or veterinary use.

Synonym

SynonymsAY 22989;NSC-2260804;Sirolimus;Rapamycin

Property

Molecular Formula: C51H79NO13
Molecular Weight914.19
Target:mTOR
Solubility>45.7mg/mL in DMSO
Purity≥95%
StorageDesiccate at -20°C
MDLMFCD00867594
Overview of Clinical Research<span style=”font-family:arial,helvetica,sans-serif;”><span style=”color:#000000;”><span style=”font-size:12px;”>Rapamycin is a&nbsp;<span style=”caret-color: rgb(102, 102, 102); orphans: 2; widows: 2;”>MTOR protein inhibitor and a T lymphocyte inhibitor. It receives the orphan drug status in&nbsp;</span><span style=”font-variant-ligatures: normal; orphans: 2; widows: 2;”>Lymphangioleiomyomatosis and Fibroma. The&nbsp;</span><span style=”font-variant-ligatures: normal; orphans: 2; widows: 2;”>Phase-III clinical trials in Neurofibromatosis 1 (In adults, In children, In the elderly) in Japan (unspecified route) (NCT04461886) started in 2020.</span></span></span></span>

Computed Descriptor

IUPAC Name(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone
InChIInChI=1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44
InChIKeyQFJCIRLUMZQUOT-HPLJOQBZSA-N
SMILESCC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)O)C)C)O)OC)C)C)C)OC