Rafoxanide（Cat No.:I002733） is a salicylanilide compound that exhibits antiparasitic activity against a variety of internal parasites, particularly in veterinary medicine. It is commonly used to treat infections caused by gastrointestinal nematodes and trematodes in animals. Rafoxanide works by interfering with the energy metabolism of the parasites, leading to their paralysis and eventual death.
| Catalog Number | I002733 |
| CAS Number | 22662-39-1 |
| Molecular Formula | C19H11Cl2I2NO3 |
| Purity | ≥95% |
| Solubility | soluble in chloroform(> 10 mM) |
| Storage | 2-8°C |
| IUPAC Name | N-[3-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3,5-diiodobenzamide |
| InChI | InChI=1S/C19H11Cl2I2NO3/c20-10-1-4-13(5-2-10)27-17-6-3-12(9-15(17)21)24-19(26)14-7-11(22)8-16(23)18(14)25/h1-9,25H,(H,24,26) |
| InChIKey | NEMNPWINWMHUMR-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC=C1OC2=C(C=C(C=C2)NC(=O)C3=C(C(=CC(=C3)I)I)O)Cl)Cl |
| Reference | </br>1:Self-Association of Rafoxanide in Aqueous Media and Its Application in Preparing Amorphous Solid Dispersions. Meng F, Liu T, Schneider E, Alzobaidi S, Gil M, Zhang F.Mol Pharm. 2017 May 1;14(5):1790-1799. doi: 10.1021/acs.molpharmaceut.7b00068. Epub 2017 Apr 17. PMID: 28375620 </br>2:Rafoxanide and Closantel Inhibit SPAK and OSR1 Kinases by Binding to a Highly Conserved Allosteric Site on Their C-terminal Domains. AlAmri MA, Kadri H, Alderwick LJ, Simpkins NS, Mehellou Y.ChemMedChem. 2017 May 9;12(9):639-645. doi: 10.1002/cmdc.201700077. Epub 2017 Apr 12. PMID: 28371477 </br>3:Validated UPLC and TLC-Densitometry Stability Indicating Methods for the Determination of Rafoxanide in the Presence of Its Degradation Products. Saad AS, Hamdy AM, Salama FM, Abdelkawy M.J Chromatogr Sci. 2016 Jul 1. pii: bmw112. [Epub ahead of print] PMID: 27368343 </br>4:Comparative study on the selectivity of various spectrophotometric techniques for the determination of binary mixture of fenbendazole and rafoxanide. Saad AS, Attia AK, Alaraki MS, Elzanfaly ES.Spectrochim Acta A Mol Biomol Spectrosc. 2015 Nov 5;150:682-90. doi: 10.1016/j.saa.2015.05.098. Epub 2015 Jun 4. PMID: 26093118 </br>5:Investigation of the persistence of rafoxanide residues in bovine milk and fate during processing. Power C, Danaher M, Sayers R, O/’Brien B, Whelan M, Furey A, Jordan K.Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2013;30(6):1087-95. doi: 10.1080/19440049.2013.787655. Epub 2013 May 28. PMID: 23713694 </br>6:An improved thyroid hormone reporter assay to determine the thyroid hormone-like activity of amiodarone, bithionol, closantel and rafoxanide. Matsubara K, Sanoh S, Ohta S, Kitamura S, Sugihara K, Fujimoto N.Toxicol Lett. 2012 Jan 5;208(1):30-5. doi: 10.1016/j.toxlet.2011.10.004. Epub 2011 Oct 13. PMID: 22015988 </br>7:Determination of closantel and rafoxanide in animal tissues by online anionic mixed-mode solid-phase extraction followed by isotope dilution liquid chromatography tandem mass spectrometry. Lai SS, Yeung HS, Lee WO, Ho C, Wong YT.J Sep Sci. 2011 Jun;34(12):1366-74. doi: 10.1002/jssc.201000675. Epub 2011 May 10. PMID: 21560244 </br>8:Quantitative analysis of closantel and rafoxanide in bovine and ovine muscles by high-performance liquid chromatography with fluorescence detection. Yeung HS, Ching WH, Lai SS, Lee WO, Wong YT.J AOAC Int. 2010 Sep-Oct;93(5):1672-7. PMID: 21140680 </br>9:Screening of closantel and rafoxanide in animal muscles by HPLC with fluorescence detection and confirmation using MS. Yeung HS, Lee WO, Wong YT.J Sep Sci. 2010 Feb;33(2):206-11. doi: 10.1002/jssc.200900503. PMID: 19998374 </br>10:Comparative pharmacokinetics of ivermectin alone and a novel formulation of ivermectin and rafoxanide in calves and sheep. El-Banna HA, Goudah A, El-Zorba H, Abd-El-Rahman S.Parasitol Res. 2008 May;102(6):1337-42. doi: 10.1007/s00436-008-0915-6. Epub 2008 Feb 23. PMID: 18297309 |
