For research use only. Not for therapeutic Use.
(Rac)-WAY-161503(CAT: R065498) is a potent and selective 5-HT₂C receptor agonist, exhibiting high affinity (Ki = 4 nM) and strong efficacy (EC₅₀ = 12 nM). It demonstrates preferential binding for 5-HT₂C receptors over 5-HT₂A and 5-HT₂B subtypes, underscoring its selectivity. Preclinical studies reveal that (Rac)-WAY-161503 produces significant anti-obesity and antidepressant effects, making it a valuable pharmacological probe for serotonergic signaling. In vivo, intraperitoneal administration (3–30 mg/kg) reduces locomotor activity in mice, an effect reversed by the 5-HT₂C/2B antagonist SER-082. This compound serves as an important research tool for studying serotonin receptor pharmacology, mood regulation, and metabolic disorders.
| CAS Number | 75704-24-4 |
| Synonyms | 8,9-dichloro-1,2,3,4,4a,6-hexahydropyrazino[1,2-a]quinoxalin-5-one |
| Molecular Formula | C11H11Cl2N3O |
| Purity | ≥95% |
| IUPAC Name | 8,9-dichloro-1,2,3,4,4a,6-hexahydropyrazino[1,2-a]quinoxalin-5-one |
| InChI | InChI=1S/C11H11Cl2N3O/c12-6-3-8-9(4-7(6)13)16-2-1-14-5-10(16)11(17)15-8/h3-4,10,14H,1-2,5H2,(H,15,17) |
| InChIKey | PHGWDAICBXUJDU-UHFFFAOYSA-N |
| SMILES | C1CN2C(CN1)C(=O)NC3=CC(=C(C=C32)Cl)Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
