(Rac)-Razpipadon

• CAT Number: I045277
• CAS Number: 1643462-93-4
• Molecular Formula: C19H17F2N3O4
• Molecular Weight: 389.35
• Purity: ≥95%
• Synonyms: 6-[4-[3-(difluoromethoxy)pyridin-2-yl]oxy-2-methylphenyl]-1,5-dimethylpyrimidine-2,4-dione
• InChI: InChI=1S/C19H17F2N3O4/c1-10-9-12(27-17-14(28-18(20)21)5-4-8-22-17)6-7-13(10)15-11(2)16(25)23-19(26)24(15)3/h4-9,18H,1-3H3,(H,23,25,26)
• InChIKey: ZXIPVZWZRQCIRW-UHFFFAOYSA-N
• SMILES: CC1=C(C=CC(=C1)OC2=C(C=CC=N2)OC(F)F)C3=C(C(=O)NC(=O)N3C)C

(Rac)-Razpipadon（Cat No.:I045277）, also known as PW‑0464, is a racemic, non‑catechol dopamine D₁ receptor agonist featuring strong G‑protein signaling bias and nanomolar potency. It selectively activates D₁ (and likely D₅) receptors, triggering cAMP accumulation with an EC₅₀ of approximately 5.8 nM, while showing minimal β‑arrestin recruitment—demonstrating full G‑protein pathway bias. It is used as a research tool in neurological studies, particularly for dopamine-related signaling and disorders, offering precise modulation of G‑protein–mediated receptor activity without engaging arrestin-dependent pathways.