(Rac)-PF-06256142

• CAT Number: I045543
• CAS Number: 1609580-97-3
• Molecular Formula: C21H16N4O2
• Molecular Weight: 356.38
• Purity: ≥95%
• Synonyms: 4-[3-methyl-4-(6-methylimidazo[1,2-a]pyrazin-5-yl)phenoxy]furo[3,2-c]pyridine
• InChI: InChI=1S/C21H16N4O2/c1-13-11-15(27-21-17-6-10-26-18(17)5-7-23-21)3-4-16(13)20-14(2)24-12-19-22-8-9-25(19)20/h3-12H,1-2H3
• InChIKey: HWAIAGZSWHOLLK-UHFFFAOYSA-N
• SMILES: CC1=C(C=CC(=C1)OC2=NC=CC3=C2C=CO3)C4=C(N=CC5=NC=CN54)C

(Rac)-PF-06256142 (Cat No.: I045543) is the racemic mixture of PF-06256142, a muscarinic M1 receptor positive allosteric modulator (PAM) developed by Pfizer. Unlike direct agonists, it enhances acetylcholine signaling through allosteric modulation, providing greater specificity and reduced side effects. The racemic form contains both (R)- and (S)-enantiomers, making it useful for comparative pharmacological studies and structure–activity relationship research. (Rac)-PF-06256142 has been investigated for potential roles in cognition, memory, and neuropsychiatric disorders such as Alzheimer’s disease and schizophrenia, supporting drug discovery in neuroscience.

Reference

[1]. Davoren JE, et al. Discovery and Lead Optimization of Atropisomer D1 Agonists with Reduced Desensitization. J Med Chem. 2018 Nov 15.
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