RA839

• CAT Number: I011276
• CAS Number: 1832713-02-6
• Molecular Formula: C25H28N2O4S
• Molecular Weight: 452.57
• Purity: ≥95%
• Synonyms: (3S)-1-[4-[(2,3,5,6-tetramethylphenyl)sulfonylamino]naphthalen-1-yl]pyrrolidine-3-carboxylic acid
• InChI: InChI=1S/C25H28N2O4S/c1-15-13-16(2)18(4)24(17(15)3)32(30,31)26-22-9-10-23(21-8-6-5-7-20(21)22)27-12-11-19(14-27)25(28)29/h5-10,13,19,26H,11-12,14H2,1-4H3,(H,28,29)/t19-/m0/s1
• InChIKey: BVYWIQHJXAEJOD-IBGZPJMESA-N
• SMILES: CC1=CC(=C(C(=C1C)S(=O)(=O)NC2=CC=C(C3=CC=CC=C32)N4CC[C@@H](C4)C(=O)O)C)C

RA839（Cat No.:I011276）is a potent and selective activator of the NLRP3 inflammasome, a key component of the innate immune system involved in the detection of cellular stress and pathogens. By promoting NLRP3 activation, RA839 induces caspase-1 activation and subsequent maturation of pro-inflammatory cytokines such as IL-1β and IL-18. It is used in immunology research to study inflammasome signaling, host defense mechanisms, and inflammatory disease models. RA839 serves as a valuable tool for dissecting the regulation of NLRP3 activity and exploring therapeutic strategies targeting inflammation and immune-related disorders.