For research use only. Not for therapeutic Use.
(R)-PS210(CAT: I016812) is the R-enantiomer of PS210 (compound 4h-eutomer), characterized as a substrate-selective allosteric activator of 3-phosphoinositide-dependent kinase-1 (PDK1). It binds to the PIF-binding pocket (PRK2-interacting fragment site) of PDK1, promoting kinase activation in a selective manner. In a cell-free kinase assay, (R)-PS210 exhibits an AC₅₀ value of 1.8 μM, achieving up to a 5.5-fold increase in PDK1 activity compared to DMSO control. This compound is a valuable chemical tool for probing PDK1 signaling, substrate selectivity, and allosteric modulation, with broad applications in oncology, cell signaling, and kinase-targeted drug discovery research.
| CAS Number | 1410101-89-1 |
| Synonyms | 2-[(1R)-3-oxo-1-phenyl-3-[4-(trifluoromethyl)phenyl]propyl]propanedioic acid |
| Molecular Formula | C19H15F3O5 |
| Purity | ≥95% |
| IUPAC Name | 2-[(1R)-3-oxo-1-phenyl-3-[4-(trifluoromethyl)phenyl]propyl]propanedioic acid |
| InChI | InChI=1S/C19H15F3O5/c20-19(21,22)13-8-6-12(7-9-13)15(23)10-14(11-4-2-1-3-5-11)16(17(24)25)18(26)27/h1-9,14,16H,10H2,(H,24,25)(H,26,27)/t14-/m0/s1 |
| InChIKey | MLJPLHGJBUWCBA-AWEZNQCLSA-N |
| SMILES | C1=CC=C(C=C1)C(CC(=O)C2=CC=C(C=C2)C(F)(F)F)C(C(=O)O)C(=O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
