For research use only. Not for therapeutic Use.
(R)-PF-06256142 (Cat No.: I045542) is a selective M1 muscarinic acetylcholine receptor positive allosteric modulator (PAM) developed by Pfizer. It enhances acetylcholine-mediated signaling without directly activating the receptor, offering improved specificity compared to traditional agonists. This compound has been explored for its potential to improve cognition, learning, and memory, with applications in Alzheimer’s disease, schizophrenia, and other cognitive disorders. Its brain penetrance, potency, and receptor selectivity make (R)-PF-06256142 a valuable research tool for understanding cholinergic neurotransmission and advancing therapeutic strategies in neuroscience.
| CAS Number | 1609583-15-4 |
| Synonyms | 4-[3-methyl-4-(6-methylimidazo[1,2-a]pyrazin-5-yl)phenoxy]furo[3,2-c]pyridine |
| Molecular Formula | C21H16N4O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C21H16N4O2/c1-13-11-15(27-21-17-6-10-26-18(17)5-7-23-21)3-4-16(13)20-14(2)24-12-19-22-8-9-25(19)20/h3-12H,1-2H3 |
| InChIKey | HWAIAGZSWHOLLK-UHFFFAOYSA-N |
| SMILES | CC1=C(C=CC(=C1)OC2=NC=CC3=C2C=CO3)C4=C(N=CC5=NC=CN54)C |
| Reference | [1]. Davoren JE, et al. Discovery and Lead Optimization of Atropisomer D1 Agonists with Reduced Desensitization. J Med Chem. 2018;61(24):11384-11397. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
