(R)-ONO-2952

• CAT Number: I044178
• CAS Number: 2988224-39-9
• Molecular Formula: C22H20ClFN2O2
• Molecular Weight: 398.86
• Purity: ≥95%
• Synonyms: 1-[(1R)-1-(4-chloro-2-methoxyphenyl)-5-fluorospiro[3,9-dihydro-1H-pyrido[3,4-b]indole-4,1′-cyclopropane]-2-yl]ethanone
• IUPAC Name: 1-[(1R)-1-(4-chloro-2-methoxyphenyl)-5-fluorospiro[3,9-dihydro-1H-pyrido[3,4-b]indole-4,1'-cyclopropane]-2-yl]ethanone
• InChI: InChI=1S/C22H20ClFN2O2/c1-12(27)26-11-22(8-9-22)19-18-15(24)4-3-5-16(18)25-20(19)21(26)14-7-6-13(23)10-17(14)28-2/h3-7,10,21,25H,8-9,11H2,1-2H3/t21-/m1/s1
• InChIKey: ZBQMTQGDBFZUBG-OAQYLSRUSA-N
• SMILES: CC(=O)N1CC2(CC2)C3=C([C@H]1C4=C(C=C(C=C4)Cl)OC)NC5=C3C(=CC=C5)F

(R)-ONO-2952（Cat No.:I044178）is a selective and orally bioavailable translocator protein (TSPO) antagonist, developed for the treatment of stress-related disorders. TSPO, formerly known as the peripheral benzodiazepine receptor, is involved in mitochondrial cholesterol transport and neurosteroidogenesis. By selectively inhibiting TSPO, (R)-ONO-2952 modulates neurosteroid levels without the sedative or addictive effects associated with central benzodiazepine receptor agonists. Preclinical studies have shown its efficacy in reducing stress-induced behaviors and anxiety. (R)-ONO-2952 is a promising therapeutic candidate for conditions such as generalized anxiety disorder, irritable bowel syndrome, and other neuropsychiatric disorders.