(R)-Funapide

• CAT Number: I045065
• CAS Number: 1259933-15-7
• Molecular Formula: C22H14F3NO5
• Molecular Weight: 429.35
• Purity: ≥95%
• Synonyms: (7R)-1′-[[5-(trifluoromethyl)furan-2-yl]methyl]spiro[6H-furo[2,3-f][1,3]benzodioxole-7,3′-indole]-2′-one
• IUPAC Name: (7R)-1'-[[5-(trifluoromethyl)furan-2-yl]methyl]spiro[6H-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one
• InChI: InChI=1S/C22H14F3NO5/c23-22(24,25)19-6-5-12(31-19)9-26-15-4-2-1-3-13(15)21(20(26)27)10-28-16-8-18-17(7-14(16)21)29-11-30-18/h1-8H,9-11H2/t21-/m1/s1
• InChIKey: NEBUOXBYNAHKFV-OAQYLSRUSA-N
• SMILES: C1[C@@]2(C3=CC=CC=C3N(C2=O)CC4=CC=C(O4)C(F)(F)F)C5=CC6=C(C=C5O1)OCO6

(R)-Funapide（Cat No.:I045065）is a selective sodium channel blocker targeting Nav1.7, Nav1.8, and Nav1.9 channels, which are key mediators of pain signal transmission. As the (R)-enantiomer of funapide, it has been studied for its analgesic potential in treating chronic pain conditions such as osteoarthritis, neuropathic pain, and erythromelalgia. By modulating peripheral nociceptive pathways without affecting central nervous system function, (R)-Funapide aims to provide effective, non-opioid pain relief with a favorable safety profile. Its topical and systemic formulations are undergoing clinical evaluation to establish therapeutic viability.