For research use only. Not for therapeutic Use.
(R)-FT709(CAT: I040623) is a highly selective and potent inhibitor of USP9X, a deubiquitinating enzyme involved in protein homeostasis, apoptosis, and oncogenic signaling. By targeting USP9X, (R)-FT709 promotes the degradation of key substrates such as MCL-1 and other regulatory proteins, making it a powerful tool in cancer research, particularly for studying mechanisms of tumor survival and resistance to therapy. It enables precise modulation of the ubiquitin-proteasome system and facilitates exploration of DUB-targeted therapeutic strategies. (R)-FT709 exhibits favorable selectivity profiles, ensuring minimal off-target activity.
| CAS Number | 2413991-75-8 |
| Synonyms | (2R)-1-[5-(2,3-dihydro-[1,4]dioxino[2,3-b]pyridin-7-ylsulfonyl)-1,3,4,6-tetrahydropyrrolo[3,4-c]pyrrol-2-yl]-2-hydroxy-2-(2-methyl-1,3-benzoxazol-4-yl)ethanone |
| Molecular Formula | C23H22N4O7S |
| Purity | ≥95% |
| IUPAC Name | (2R)-1-[5-(2,3-dihydro-[1,4]dioxino[2,3-b]pyridin-7-ylsulfonyl)-1,3,4,6-tetrahydropyrrolo[3,4-c]pyrrol-2-yl]-2-hydroxy-2-(2-methyl-1,3-benzoxazol-4-yl)ethanone |
| InChI | InChI=1S/C23H22N4O7S/c1-13-25-20-17(3-2-4-18(20)34-13)21(28)23(29)26-9-14-11-27(12-15(14)10-26)35(30,31)16-7-19-22(24-8-16)33-6-5-32-19/h2-4,7-8,21,28H,5-6,9-12H2,1H3/t21-/m1/s1 |
| InChIKey | SCFWBZTVFCUBIZ-OAQYLSRUSA-N |
| SMILES | CC1=NC2=C(C=CC=C2O1)C(C(=O)N3CC4=C(C3)CN(C4)S(=O)(=O)C5=CC6=C(N=C5)OCCO6)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
