(R)-eIF4A3-IN-2

• CAT Number: I045040
• CAS Number: 2095484-82-3
• Molecular Formula: C25H19Br2ClN4O2
• Molecular Weight: 602.70
• Purity: ≥95%
• Synonyms: (4-bromophenyl)-[(2R)-4-(6-bromopyrazolo[1,5-a]pyridine-3-carbonyl)-2-(4-chlorophenyl)piperazin-1-yl]methanone
• InChI: InChI=1S/C25H19Br2ClN4O2/c26-18-5-1-17(2-6-18)24(33)31-12-11-30(15-23(31)16-3-8-20(28)9-4-16)25(34)21-13-29-32-14-19(27)7-10-22(21)32/h1-10,13-14,23H,11-12,15H2/t23-/m0/s1
• InChIKey: WKKAVTNXNVPCCN-QHCPKHFHSA-N
• SMILES: C1CN([C@@H](CN1C(=O)C2=C3C=CC(=CN3N=C2)Br)C4=CC=C(C=C4)Cl)C(=O)C5=CC=C(C=C5)Br

(R)-eIF4A3-IN-2（Cat No.:I045040）is a selective small-molecule inhibitor targeting eukaryotic initiation factor 4A3 (eIF4A3), a core component of the exon junction complex (EJC) involved in mRNA surveillance and nonsense-mediated decay. The (R)-enantiomer provides enhanced stereoselectivity and potency, making it a valuable tool in studying RNA processing and translation regulation. By inhibiting eIF4A3, this compound interferes with post-transcriptional gene expression and is of interest in cancer research where aberrant RNA metabolism contributes to tumor progression. (R)-eIF4A3-IN-2 supports the development of targeted therapies modulating RNA-binding proteins and oncogenic mRNA regulation.