(R)-DNMDP

• CAT Number: I045963
• CAS Number: 1630760-60-9
• Molecular Formula: C15H20N4O3
• Molecular Weight: 304.34
• Purity: ≥95%
• Synonyms: (4R)-3-[4-(diethylamino)-3-nitrophenyl]-4-methyl-4,5-dihydro-1H-pyridazin-6-one
• InChI: InChI=1S/C15H20N4O3/c1-4-18(5-2)12-7-6-11(9-13(12)19(21)22)15-10(3)8-14(20)16-17-15/h6-7,9-10H,4-5,8H2,1-3H3,(H,16,20)/t10-/m1/s1
• InChIKey: YOSSKNZHADPXJX-SNVBAGLBSA-N
• SMILES: CCN(CC)C1=C(C=C(C=C1)C2=NNC(=O)CC2C)[N+](=O)[O-]

(R)-DNMDP(CAT: I045963) (R-enantiomer of N,N-dimethyl-3-(2-naphthoyl)phenylalanine) is a small-molecule inhibitor known for its role as a phosphodiesterase δ (PDEδ) ligand. It binds selectively to PDEδ, a prenyl-binding protein involved in the intracellular trafficking of farnesylated proteins such as KRas. By blocking the PDEδ–KRas interaction, (R)-DNMDP disrupts KRas localization and signaling, a pathway often dysregulated in cancer. The (R)-enantiomer exhibits higher potency compared to its (S)-counterpart, making it a useful tool in cancer biology studies. This compound is employed in oncology research, particularly in the development of KRas-targeted therapies, and serves as a chemical probe for Ras pathway modulation.