For research use only. Not for therapeutic Use.
(R)-BRD3731（Cat No.:I023666）is the active enantiomer of BRD3731, a selective inhibitor of mutant isocitrate dehydrogenase 1 (IDH1), particularly the oncogenic R132H variant. This stereospecific compound inhibits the aberrant enzymatic activity of mutant IDH1, blocking the accumulation of the oncometabolite 2-hydroxyglutarate (2-HG), which is implicated in epigenetic dysregulation and impaired cellular differentiation. (R)-BRD3731 restores normal metabolic and transcriptional functions in IDH1-mutant cancer cells, showing promise in preclinical models of glioma and acute myeloid leukemia (AML). Its enantiomeric purity enhances potency and selectivity, making it a valuable tool for targeted cancer research and drug development.
| CAS Number | 2056262-08-7 |
| Synonyms | (4R)-3-(2,2-dimethylpropyl)-4,7,7-trimethyl-4-phenyl-2,6,8,9-tetrahydropyrazolo[3,4-b]quinolin-5-one |
| Molecular Formula | C24H31N3O |
| Purity | ≥95% |
| IUPAC Name | (4R)-3-(2,2-dimethylpropyl)-4,7,7-trimethyl-4-phenyl-2,6,8,9-tetrahydropyrazolo[3,4-b]quinolin-5-one |
| InChI | InChI=1S/C24H31N3O/c1-22(2,3)12-17-20-21(27-26-17)25-16-13-23(4,5)14-18(28)19(16)24(20,6)15-10-8-7-9-11-15/h7-11H,12-14H2,1-6H3,(H2,25,26,27)/t24-/m0/s1 |
| InChIKey | YZRXTIGAQRIAEX-DEOSSOPVSA-N |
| SMILES | C[C@@]1(C2=C(CC(CC2=O)(C)C)NC3=NNC(=C31)CC(C)(C)C)C4=CC=CC=C4 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
