QX-314 chloride

• CAT Number: I011801
• CAS Number: 5369-03-9
• Molecular Formula: C16H27ClN2O
• Molecular Weight: 298.85
• Purity: ≥95%
• Synonyms: [2-(2,6-dimethylanilino)-2-oxoethyl]-triethylazanium;chloride
• InChI: InChI=1S/C16H26N2O.ClH/c1-6-18(7-2,8-3)12-15(19)17-16-13(4)10-9-11-14(16)5;/h9-11H,6-8,12H2,1-5H3;1H
• InChIKey: LLPPOMUAOGMYQI-UHFFFAOYSA-N
• SMILES: CC[N+](CC)(CC)CC(=O)NC1=C(C=CC=C1C)C.[Cl-]

QX-314 chloride(CAT: I011801) is a permanently charged, membrane-impermeable sodium channel blocker widely used in electrophysiological and neuropharmacological research. Unlike conventional local anesthetics, its charged structure prevents passive membrane crossing, making it a valuable tool for intracellular applications. QX-314 exhibits biphasic modulation of TRPV1 channels, directly activating them in a concentration-dependent manner (1–60 mM). At 10 mM, it inhibits calcium currents in hippocampal CA1 pyramidal neurons, significantly reducing low-threshold (T-type) Ca²⁺ currents to less than 45% of control amplitude. This compound is commonly employed to study ion channel mechanisms, neuronal excitability, and pain signaling pathways.