QTX125 TFA

• CAT Number: I045537
• CAS Number: 2989537-78-0
• Molecular Formula: C25H20F3N3O7
• Molecular Weight: 531.44
• Purity: ≥95%
• Synonyms: 3-(furan-3-yl)-N-[[4-(hydroxycarbamoyl)phenyl]methyl]-5-(4-hydroxyphenyl)-1H-pyrrole-2-carboxamide;2,2,2-trifluoroacetic acid
• InChI: InChI=1S/C23H19N3O5.C2HF3O2/c27-18-7-5-15(6-8-18)20-11-19(17-9-10-31-13-17)21(25-20)23(29)24-12-14-1-3-16(4-2-14)22(28)26-30;3-2(4,5)1(6)7/h1-11,13,25,27,30H,12H2,(H,24,29)(H,26,28);(H,6,7)
• InChIKey: YVRBCQZCFZYITL-UHFFFAOYSA-N
• SMILES: C1=CC(=CC=C1CNC(=O)C2=C(C=C(N2)C3=CC=C(C=C3)O)C4=COC=C4)C(=O)NO.C(=O)(C(F)(F)F)O

QTX125 TFA (Cat No.: I045537) is a small-molecule inhibitor formulated as the trifluoroacetate (TFA) salt to improve stability and solubility for laboratory use. It has been identified as a selective modulator of epigenetic regulatory proteins, influencing chromatin dynamics and transcriptional control. QTX125 TFA is primarily employed in preclinical research to investigate its effects on cancer cell proliferation, differentiation, and survival, as well as potential roles in inflammatory and metabolic pathways. Its selectivity makes it a valuable tool for probing therapeutic epigenetic mechanisms.

Reference

[1]. Montserrat Pérez-Salvia, et al. In vitro and in vivo activity of a new small-molecule inhibitor of HDAC6 in mantle cell lymphoma. Haematologica. 2018 Nov;103(11):e537-e540.
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