QO58（Cat No.:I008858）is a small-molecule activator of two-pore domain potassium (K2P) channels, particularly TREK-1 and TRAAK, which are involved in regulating neuronal excitability, pain perception, and neuroprotection. By enhancing K2P channel activity, QO58 promotes potassium efflux, leading to membrane hyperpolarization and reduced cellular excitability. It is widely used in neuroscience research to study ion channel physiology, pain mechanisms, and neuroprotective responses under stress conditions such as ischemia. QO58 serves as a valuable tool for investigating the therapeutic potential of K2P channel modulators in pain management and neurological disorders.