QM31

• CAT Number: I017407
• CAS Number: 937735-00-7
• Molecular Formula: C₃₉H₃₈Cl₄N₄O₄
• Molecular Weight: 768.56
• Purity: ≥95%

QM31(CAT: I017407), also known as SVT016426, is a cytoprotective agent that acts as a selective inhibitor of Apaf-1. It effectively inhibits the formation of the apoptosome, which is the caspase activation complex composed of Apaf-1, cytochrome c, dATP, and caspase-9. With an IC50 of 7.9 μM, QM31 hinders the assembly of the apoptosome, thereby preventing caspase activation. Additionally, QM31 exhibits mitochondria protective properties and interferes with the intra-S-phase DNA damage checkpoint. In HeLa S100 cells, SVT016426 inhibits Apaf1-induced activation of caspase activity with an IC50 of 5 μM. These findings suggest the potential of QM31 as a therapeutic agent for modulating apoptotic pathways and protecting against cellular damage.

Reference

[1]. Mondragón L, et al. A chemical inhibitor of Apaf-1 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint. Apoptosis. 2009 Feb;14(2):182-90.[2]. Orzáez M, et al. Apaf-1 inhibitors protect from unwanted cell death in in vivo models of kidney ischemia and chemotherapy induced ototoxicity. PLoS One. 2014 Oct 20;9(10):e110979.[3]. Gortat A, et al. Apaf1 inhibition promotes cell recovery from apoptosis. Protein Cell. 2015 Nov;6(11):833-43.