Pyridoxal isonicotinoyl hydrazine is a lipophilic, nontoxic, iron-chelating agent that shows high iron chelation efficacy both <em>in vitro</em> in cell culture models and <em>in vivo</em> in rats and mice. Because iron is a crucial component of metabolic pathways involved in DNA synthesis, cancerous cells have a high iron requirement due to rapid rates of proliferation. While pyridoxal isonicotinoyl hydrazine exhibits low anticancer activity, its analogs demonstrate antiproliferative effects in a range of tumor cells.
| Catalog Number | R066321 |
| CAS Number | 737-86-0 |
| Synonyms | NSC 77674;PIH |
| Molecular Formula | C14H14N4O3 |
| Purity | 95% |
| Storage | -20°C |
| InChI | InChI=1S/C14H14N4O3/c1-9-13(20)12(11(8-19)6-16-9)7-17-18-14(21)10-2-4-15-5-3-10/h2-7,19-20H,8H2,1H3,(H,18,21)/b17-7+ |
| InChIKey | BQYIXOPJPLGCRZ-REZTVBANSA-N |
| SMILES | CC1=NC=C(CO)C(/C=N/NC(C2=CC=NC=C2)=O)=C1O |
| Reference | 1.Ponka, P.,Borova, J.,Neuwirt, J., et al. Mobilization of iron from reticulocytes. Identification of pyridoxal isonicotinoyl hydrazone as a new iron chelating agent. FEBS Letters 97(2), 317-321 (1979). |
