Pyridoxal isonicotinoyl hydrazone

  • CAT Number: R066321
  • CAS Number: 737-86-0
  • Molecular Formula: C14H14N4O3
  • Molecular Weight: 286.3
  • Purity: ≥95%
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Pyridoxal isonicotinoyl hydrazine is a lipophilic, nontoxic, iron-chelating agent that shows high iron chelation efficacy both <em>in vitro</em> in cell culture models and <em>in vivo</em> in rats and mice. Because iron is a crucial component of metabolic pathways involved in DNA synthesis, cancerous cells have a high iron requirement due to rapid rates of proliferation. While pyridoxal isonicotinoyl hydrazine exhibits low anticancer activity, its analogs demonstrate antiproliferative effects in a range of tumor cells.

Catalog Number R066321
CAS Number 737-86-0
Molecular Formula


Purity 95%
Storage -20°C
InChI InChI=1S/C14H14N4O3/c1-9-13(20)12(11(8-19)6-16-9)7-17-18-14(21)10-2-4-15-5-3-10/h2-7,19-20H,8H2,1H3,(H,18,21)/b17-7+

1.Ponka, P.,Borova, J.,Neuwirt, J., et al. Mobilization of iron from reticulocytes. Identification of pyridoxal isonicotinoyl hydrazone as a new iron chelating agent. FEBS Letters 97(2), 317-321 (1979).

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