Pyridoxal 5'-phosphate (hydrate)

• CAT Number: R066746
• CAS Number: 853645-22-4
• Molecular Formula: C8H10NO6P
• Molecular Weight: 247.143
• Purity: ≥95%
• Synonyms: 3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]-4-pyridinecarboxaldehyde, hydrate
• Storage: Room temperature
• IUPAC Name: (4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate
• InChI: InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
• InChIKey: NGVDGCNFYWLIFO-UHFFFAOYSA-N
• SMILES: CC1=NC=C(C(=C1O)C=O)COP(=O)(O)O

Pyridoxal 5′-phosphate, the active form of vitamin B6, is a cofactor for many different enzymes involved in transamination reactions, including mitochondrial cysteine desulfurase, cystathionine γ-synthase, various aminotransferases, and d-serine dehydratase. It has been used to study the pyridoxal 5′-phosphate-dependent active sites of these enzymes.

Reference

1.Zhu, W.,Lin, A. and Banerjee, R. Kinetic properties of polymorphic variants and pathogenic mutants in human cystathionine γ-lyase. Biochemistry 47, 6226-6232 (2008).