Pyoluteorin

• CAT Number: R021845
• CAS Number: 25683-07-2
• Molecular Formula: C11H7Cl2NO3
• Molecular Weight: 272.08
• Purity: ≥95%
• Synonyms: (4,5-dichloro-1H-pyrrol-2-yl)-(2,6-dihydroxyphenyl)methanone
• InChI: InChI=1S/C11H7Cl2NO3/c12-5-4-6(14-11(5)13)10(17)9-7(15)2-1-3-8(9)16/h1-4,14-16H
• InChIKey: JPGWTZORMBTNMF-UHFFFAOYSA-N
• SMILES: C1=CC(=C(C(=C1)O)C(=O)C2=CC(=C(N2)Cl)Cl)O

Pyoluteorin (Cat No.: R021845) is a halogenated polyketide–pyrrole antibiotic naturally produced by Pseudomonas species. It exhibits strong antifungal activity, particularly against plant pathogens such as Pythium and Rhizoctonia, by disrupting membrane integrity and inhibiting fungal growth. Pyoluteorin also shows antibacterial and cytotoxic properties, making it of interest in both agricultural and biomedical research. Beyond its antimicrobial effects, it serves as a model compound for studying halogenated secondary metabolites, microbial chemical ecology, and the regulatory networks controlling antibiotic biosynthesis in beneficial rhizobacteria.

Reference

[1]. B Nowak-Thompson, et al. Characterization of the pyoluteorin biosynthetic gene cluster of Pseudomonas fluorescens Pf-5. J Bacteriol. 1999 Apr;181(7):2166-74.
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[2]. Ting Ding, et al. Pyoluteorin induces cell cycle arrest and apoptosis in human triple-negative breast cancer cells MDA-MB-231. J Pharm Pharmacol. 2020 Jul;72(7):969-978.
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