For research use only. Not for therapeutic Use.
PY-60（Cat No.:I045258）is a potent, selective inhibitor of the transcriptional coactivator Yes-associated protein (YAP), a key effector in the Hippo signaling pathway that regulates cell proliferation, apoptosis, and tissue homeostasis. By disrupting YAP–TEAD interactions, PY-60 suppresses transcription of YAP target genes involved in oncogenesis, fibrosis, and regenerative processes. This compound is valuable for studying YAP-driven cancers, including hepatocellular carcinoma and mesothelioma, as well as fibrotic diseases. Its specificity and suitability for cell-based assays make PY-60 an important research tool for investigating Hippo pathway regulation and developing targeted anti-YAP therapeutic strategies.
| CAS Number | 2765218-56-0 |
| Synonyms | 5-phenyl-N-[3-(1,3-thiazol-2-yl)propyl]-1,2-oxazole-3-carboxamide |
| Molecular Formula | C16H15N3O2S |
| Purity | ≥95% |
| IUPAC Name | 5-phenyl-N-[3-(1,3-thiazol-2-yl)propyl]-1,2-oxazole-3-carboxamide |
| InChI | InChI=1S/C16H15N3O2S/c20-16(18-8-4-7-15-17-9-10-22-15)13-11-14(21-19-13)12-5-2-1-3-6-12/h1-3,5-6,9-11H,4,7-8H2,(H,18,20) |
| InChIKey | UFASECSYKSMYET-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)C2=CC(=NO2)C(=O)NCCCC3=NC=CS3 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
