For research use only. Not for therapeutic Use.
PXS-4728A（Cat No.:I008921）, also known as BI 1467335, is a selective, irreversible inhibitor of semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 (SSAO/VAP-1). By blocking VAP-1 enzymatic activity, PXS-4728A reduces oxidative stress, leukocyte adhesion, and tissue inflammation. Preclinical and clinical studies indicate its potential in treating nonalcoholic steatohepatitis (NASH), diabetic retinopathy, and other chronic inflammatory or fibrotic diseases. Its favorable oral bioavailability and target specificity make it a strong candidate for therapeutic development. PXS-4728A serves as a valuable research tool for exploring vascular inflammation and metabolic disease interventions.
| CAS Number | 1478364-68-9 |
| Synonyms | 4-[(E)-2-(aminomethyl)-3-fluoroprop-2-enoxy]-N-tert-butylbenzamide;hydrochloride |
| Molecular Formula | C15H22ClFN2O2 |
| Purity | ≥95% |
| IUPAC Name | 4-[(E)-2-(aminomethyl)-3-fluoroprop-2-enoxy]-N-tert-butylbenzamide;hydrochloride |
| InChI | InChI=1S/C15H21FN2O2.ClH/c1-15(2,3)18-14(19)12-4-6-13(7-5-12)20-10-11(8-16)9-17;/h4-8H,9-10,17H2,1-3H3,(H,18,19);1H/b11-8+; |
| InChIKey | AEMZEDNMNLIDSL-YGCVIUNWSA-N |
| SMILES | CC(C)(C)NC(=O)C1=CC=C(C=C1)OC/C(=C/F)/CN.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
