For research use only. Not for therapeutic Use.
PW0787（Cat No.:I035231）is a potent, selective inhibitor of the MLLT1/3 YEATS domain, developed to disrupt chromatin reader functions involved in acute leukemia. By specifically targeting the YEATS domain, PW0787 impairs the recognition of acetylated histones, thereby modulating gene expression linked to leukemogenesis. It has demonstrated high affinity and selectivity in biochemical and cellular assays, making it a valuable tool for studying epigenetic regulation in cancer. PW0787’s ability to block oncogenic transcription programs highlights its potential as a lead compound for novel therapies targeting epigenetic readers in hematologic malignancies.
| CAS Number | 2624131-45-7 |
| Synonyms | 1-[6-[[3-fluoro-5-(trifluoromethyl)phenyl]methyl]pyrimidin-4-yl]-N-(2-hydroxyethyl)-2,3-dihydroindole-4-carboxamide |
| Molecular Formula | C23H20F4N4O2 |
| Purity | ≥95% |
| IUPAC Name | 1-[6-[[3-fluoro-5-(trifluoromethyl)phenyl]methyl]pyrimidin-4-yl]-N-(2-hydroxyethyl)-2,3-dihydroindole-4-carboxamide |
| InChI | InChI=1S/C23H20F4N4O2/c24-16-9-14(8-15(11-16)23(25,26)27)10-17-12-21(30-13-29-17)31-6-4-18-19(2-1-3-20(18)31)22(33)28-5-7-32/h1-3,8-9,11-13,32H,4-7,10H2,(H,28,33) |
| InChIKey | OLNVWBLTVAPNME-UHFFFAOYSA-N |
| SMILES | C1CN(C2=CC=CC(=C21)C(=O)NCCO)C3=NC=NC(=C3)CC4=CC(=CC(=C4)F)C(F)(F)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
