Purmorphamine - CAS 483367-10-8

Purmorphamine(Cat No.:I003702) is a compound that interacts directly with Smoothened (Smo), a key component of the Hedgehog signaling pathway. It functions by binding to Smo, inhibiting the binding of BODIPY-cyclopamine to Smo with an IC50 of approximately 1.5 μM. Additionally, purmorphamine acts as an inducer of osteoblast differentiation, promoting the formation of bone-forming cells. Its osteogenic activity is demonstrated by an EC50 of 1 μM, indicating its potential therapeutic application in promoting bone regeneration and treating bone-related disorders.

Catalog Number: I003702

CAS Number: 483367-10-8

PubChem Substance ID:355039968

Molecular Formula: C31H32N6O2

Molecular Weight:520.62

Purity: ≥95%

Inventory:In stock

* For research use only. Not for human or veterinary use.

Synonym

Synonyms9-cyclohexyl-N-(4-morpholin-4-ylphenyl)-2-naphthalen-1-yloxypurin-6-amine

Property

Molecular Formula: C31H32N6O2
Molecular Weight520.62
Target:Smoothened
Solubility10 mM in DMSO
Purity≥95%
StorageStore at -20°C
IC501.5 uM

Computed Descriptor

IUPAC Name9-cyclohexyl-N-(4-morpholin-4-ylphenyl)-2-naphthalen-1-yloxypurin-6-amine
InChIInChI=1S/C31H32N6O2/c1-2-9-25(10-3-1)37-21-32-28-29(33-23-13-15-24(16-14-23)36-17-19-38-20-18-36)34-31(35-30(28)37)39-27-12-6-8-22-7-4-5-11-26(22)27/h4-8,11-16,21,25H,1-3,9-10,17-20H2,(H,33,34,35)
InChIKeyFYBHCRQFSFYWPY-UHFFFAOYSA-N
SMILESC1CCC(CC1)N2C=NC3=C(N=C(N=C32)OC4=CC=CC5=CC=CC=C54)NC6=CC=C(C=C6)N7CCOCC7