For research use only. Not for therapeutic Use.
PU141 (Cat No.: I035198) is a small-molecule inhibitor designed to target heat shock protein 90 (HSP90), a molecular chaperone essential for stabilizing and activating many oncogenic client proteins. By disrupting HSP90 function, PU141 promotes degradation of these proteins, impairing pathways that support tumor growth and survival. It has been studied in preclinical models as a potential anticancer agent, particularly in malignancies driven by HSP90-dependent signaling. PU141 serves as a valuable chemical probe for exploring protein homeostasis and the development of targeted cancer therapeutics.
| CAS Number | 168334-34-7 |
| Synonyms | 2-[[4-(trifluoromethyl)phenyl]methyl]-[1,2]thiazolo[5,4-b]pyridin-3-one |
| Molecular Formula | C14H9F3N2OS |
| Purity | ≥95% |
| InChI | InChI=1S/C14H9F3N2OS/c15-14(16,17)10-5-3-9(4-6-10)8-19-13(20)11-2-1-7-18-12(11)21-19/h1-7H,8H2 |
| InChIKey | UQVNCGIZTSUQOC-UHFFFAOYSA-N |
| SMILES | C1=CC2=C(N=C1)SN(C2=O)CC3=CC=C(C=C3)C(F)(F)F |
| Reference | [1]. M Gajer,et al. Histone acetyltransferase inhibitors block neuroblastoma cell growth in vivo. Oncogenesis.2015 Feb 9;4(2):e137. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
