PTGR2-IN-1

• CAT Number: I045514
• CAS Number: 349093-44-3
• Molecular Formula: C19H22N2O2
• Molecular Weight: 310.39
• Purity: ≥95%
• Synonyms: 1-[4-(2-methoxyphenyl)piperazin-1-yl]-2-phenylethanone
• InChI: InChI=1S/C19H22N2O2/c1-23-18-10-6-5-9-17(18)20-11-13-21(14-12-20)19(22)15-16-7-3-2-4-8-16/h2-10H,11-15H2,1H3
• InChIKey: TVIOYMPBWXQRRQ-UHFFFAOYSA-N
• SMILES: COC1=CC=CC=C1N2CCN(CC2)C(=O)CC3=CC=CC=C3

PTGR2-IN-1 (Cat No.: I045514) is a selective small-molecule inhibitor of prostaglandin reductase 2 (PTGR2), an enzyme involved in prostaglandin metabolism and redox regulation. By blocking PTGR2 activity, it modulates oxidative stress pathways, lipid mediator balance, and cellular redox homeostasis. Researchers use PTGR2-IN-1 to study mechanisms of inflammation, cancer metabolism, and oxidative stress–related diseases. Its specificity provides a powerful tool for dissecting prostaglandin signaling and exploring therapeutic strategies targeting redox regulation, inflammatory responses, and tumor progression in preclinical biomedical research.

Reference

[1]. Parker CG, et al. Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017;168(3):527-541.e29.
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