PSI-7409

• CAT Number: I013531
• CAS Number: 1015073-42-3
• Molecular Formula: C₁₀H₁₆FN₂O₁₄P₃
• Molecular Weight: 500.16
• Purity: ≥95%
• Target: HCV
• Solubility: DMSO
• Storage: Store at -20°C
• IUPAC Name: [[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
• InChI: InChI=1S/C10H16FN2O14P3/c1-10(11)7(15)5(25-8(10)13-3-2-6(14)12-9(13)16)4-24-29(20,21)27-30(22,23)26-28(17,18)19/h2-3,5,7-8,15H,4H2,1H3,(H,20,21)(H,22,23)(H,12,14,16)(H2,17,18,19)/t5-,7-,8-,10-/m1/s1
• InChIKey: IPHULAIUXUVCHH-VPCXQMTMSA-N
• SMILES: CC1(C(C(OC1N2C=CC(=O)NC2=O)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)F

PSI-7409（Cat No.:I013531） is the biologically active form of Sofosbuvir (PSI-7977), a potent and selective inhibitor of the hepatitis C virus (HCV). Sofosbuvir is a nucleotide analog that targets the NS5B RNA polymerase of HCV, and it is highly effective against multiple HCV genotypes with a high barrier to resistance. Once inside cells, Sofosbuvir is metabolized to the active form, PSI-7409, which is incorporated into the HCV RNA by NS5B, leading to chain termination and inhibition of viral replication. Sofosbuvir is used in combination with other antiviral drugs to treat chronic HCV infection.

Reference

[1]. Lam AM, et al. PSI-7851, a pronucleotide of beta-D-2//’-deoxy-2//’-fluoro-2//’-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication. Antimicrob Agents Chemother. 2010 Aug;54(8):3187-96.[2]. Murakami E, et al. Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977.