For research use only. Not for therapeutic Use.
PSB36（Cat No.:I010497）is a highly potent and selective antagonist of the adenosine A₁ receptor (A₁R), exhibiting a Ki of 0.12 nM for rat A₁R and 0.7 nM for human A₁R. It demonstrates significantly lower affinity for other adenosine receptor subtypes, with Ki values of 187 nM for A₂B, 552 nM for A₂A, and 2300 nM for A₃ receptors, underscoring its selectivity . PSB36 has been utilized in research to modulate spinal antinociception in animal models, indicating its potential in pain management studies . Additionally, it has been shown to reduce atrial fibrillation in isolated rat heart preparations, suggesting cardiovascular applications .
| CAS Number | 524944-72-7 |
| Synonyms | 1-butyl-3-(3-hydroxypropyl)-8-(3-tricyclo[3.3.1.03,7]nonanyl)-7H-purine-2,6-dione |
| Molecular Formula | C21H30N4O3 |
| Purity | ≥95% |
| IUPAC Name | 1-butyl-3-(3-hydroxypropyl)-8-(3-tricyclo[3.3.1.03,7]nonanyl)-7H-purine-2,6-dione |
| InChI | InChI=1S/C21H30N4O3/c1-2-3-5-25-18(27)16-17(24(20(25)28)6-4-7-26)23-19(22-16)21-11-13-8-14(12-21)10-15(21)9-13/h13-15,26H,2-12H2,1H3,(H,22,23) |
| InChIKey | CIBIXJYFYPFMTN-UHFFFAOYSA-N |
| SMILES | CCCCN1C(=O)C2=C(N=C(N2)C34CC5CC(C3)CC4C5)N(C1=O)CCCO |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
