PSB 0777 ammonium hydrate

• CAT Number: I041015
• Molecular Formula: C18H20N5O7S2.NH4.1.75H2O
• Molecular Weight: 532.09
• Purity: ≥95%

PSB 0777 ammonium hydrate (Cat No.: I041015) is a selective adenosine A₂B receptor agonist, used in cardiovascular and immunological research. By activating A₂B receptors, PSB 0777 modulates inflammatory responses, vasodilation, and tissue protection under hypoxic or stress conditions. Its high selectivity allows researchers to dissect A₂B-mediated signaling without interference from other adenosine receptor subtypes. The ammonium hydrate form enhances solubility for biological assays. PSB 0777 is a valuable tool for exploring adenosine pathways in inflammation, ischemia, and cancer. For research use only.

Reference

[1]. Ali El-Tayeb, et al. Development of Polar Adenosine A2A Receptor Agonists for Inflammatory Bowel Disease: Synergism with A2B Antagonists. ACS Med Chem Lett. 2011 Oct 10;2(12):890-5.
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[2]. Jesse Lea Carlin, et al.Activation of adenosine A 2A or A 2B receptors causes hypothermia in mice. Neuropharmacology. 2018 Sep 1;139:268-278.
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[3]. L Antonioli, et al. Anti-inflammatory effect of a novel locally acting A 2A receptor agonist in a rat model of oxazolone-induced colitis. Purinergic Signal. 2018 Mar;14(1):27-36.
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