For research use only. Not for therapeutic Use.
PS210(CAT:I017167) is a potent and selective PDK1 activator that binds the PIF-binding pocket with a Kd of 3 μM. Unlike many kinase modulators, PS210 is inactive against other protein kinases, including PDK1 downstream effectors such as S6K, PKB/Akt, and GSK3, ensuring high selectivity. In cellular assays, its prodrug PS423 functions as a substrate-selective PDK1 inhibitor by blocking S6K phosphorylation and activation. Structural studies reveal that PS210 stabilizes PDK1, particularly Arg131, influencing helix positioning near the phosphate-binding site and supporting kinase activation. This makes PS210 a valuable probe for studying PDK1 regulation, structural dynamics, and kinase signaling.
| CAS Number | 1221962-86-2 |
| Synonyms | 2-[3-oxo-1-phenyl-3-[4-(trifluoromethyl)phenyl]propyl]propanedioic acid |
| Molecular Formula | C19H15F3O5 |
| Purity | ≥95% |
| IUPAC Name | 2-[3-oxo-1-phenyl-3-[4-(trifluoromethyl)phenyl]propyl]propanedioic acid |
| InChI | InChI=1S/C19H15F3O5/c20-19(21,22)13-8-6-12(7-9-13)15(23)10-14(11-4-2-1-3-5-11)16(17(24)25)18(26)27/h1-9,14,16H,10H2,(H,24,25)(H,26,27) |
| InChIKey | MLJPLHGJBUWCBA-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)C(CC(=O)C2=CC=C(C=C2)C(F)(F)F)C(C(=O)O)C(=O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
