For research use only. Not for therapeutic Use.
PS10(CAT: I016426) is a novel, potent, ATP-competitive pan-PDK inhibitor with activity against all pyruvate dehydrogenase kinase isoforms. It demonstrates IC₅₀ values of 0.8 μM (PDK2), 0.76 μM (PDK4), 2.1 μM (PDK1), and 21.3 μM (PDK3), showing strongest affinity toward PDK2 (K_d = 239 nM) compared to Hsp90 (K_d = 47 μM). By inhibiting PDK activity, PS10 enhances pyruvate dehydrogenase function, promotes myocardial carbohydrate oxidation, and improves glucose tolerance in models of diet-induced obesity. This compound is a valuable tool for investigating metabolic regulation and holds therapeutic potential in diabetic cardiomyopathy and other metabolic disease research.
| CAS Number | 1564265-82-2 |
| Synonyms | 2-(2,4-dihydroxyphenyl)sulfonyl-1,3-dihydroisoindole-4,6-diol |
| Molecular Formula | C14H13NO6S |
| Purity | ≥95% |
| IUPAC Name | 2-(2,4-dihydroxyphenyl)sulfonyl-1,3-dihydroisoindole-4,6-diol |
| InChI | InChI=1S/C14H13NO6S/c16-9-1-2-14(13(19)4-9)22(20,21)15-6-8-3-10(17)5-12(18)11(8)7-15/h1-5,16-19H,6-7H2 |
| InChIKey | SVUZJWAAXPEMKJ-UHFFFAOYSA-N |
| SMILES | C1C2=C(CN1S(=O)(=O)C3=C(C=C(C=C3)O)O)C(=CC(=C2)O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
