Proteasome-activating peptide 1 TFA

• CAT Number: I043792
• Molecular Formula: C65H117F3N22O15S4
• Molecular Weight: 1632.02
• Purity: ≥95%
• IUPAC Name: (2S)-1-[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-1-[(2S,3S)-2-amino-3-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-sulfanylpropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-4-methylsulfanylbutanoyl]-N-[2-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2R)-1-amino-1-oxo-3-sulfanylpropan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid
• InChI: InChI=1S/C63H116N22O13S4.C2HF3O2/c1-7-36(4)48(66)61(98)85-29-15-21-46(85)58(95)78-40(19-13-27-73-63(70)71)54(91)82-44(34-100)56(93)76-39(18-12-26-72-62(68)69)52(89)75-37(16-8-10-24-64)53(90)80-42(23-31-102-6)60(97)84-28-14-20-45(84)57(94)74-32-47(86)83-49(35(2)3)59(96)79-38(17-9-11-25-65)51(88)77-41(22-30-101-5)55(92)81-43(33-99)50(67)87;3-2(4,5)1(6)7/h35-46,48-49,99-100H,7-34,64-66H2,1-6H3,(H2,67,87)(H,74,94)(H,75,89)(H,76,93)(H,77,88)(H,78,95)(H,79,96)(H,80,90)(H,81,92)(H,82,91)(H,83,86)(H4,68,69,72)(H4,70,71,73);(H,6,7)/t36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,48-,49-;/m0./s1
• InChIKey: XQPDFHFOCHVEOB-HAYJCLMBSA-N
• SMILES: CC[C@H](C)[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCSC)C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CS)C(=O)N)N.C(=O)(C(F)(F)F)O

Proteasome-activating peptide 1 TFA（Cat No.:I043792）is a synthetic peptide that enhances the activity of the proteasome, a key enzyme complex responsible for degrading unwanted or damaged proteins in cells. By binding to the proteasome, this peptide stimulates its catalytic function, promoting the breakdown of proteins involved in various cellular processes, including regulation of the cell cycle and stress responses. Proteasome-activating peptide 1 TFA is valuable in research focused on protein degradation, cancer biology, and neurodegenerative diseases, where proteasomal activity is crucial for maintaining cellular homeostasis and preventing protein aggregation.