Protease-Activated Receptor-3 (PAR-3) (1-6), human TFA

• CAT Number: I044269
• Molecular Formula: C31H47F3N10O9
• Molecular Weight: 760.76
• Purity: ≥95%
• Synonyms: (2S)-1-[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]propanoyl]pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid
• InChI: InChI=1S/C29H46N10O7.C2HF3O2/c1-16(28(46)39-13-7-11-21(39)24(31)42)36-22(41)15-35-25(43)19(10-6-12-34-29(32)33)37-26(44)20(14-18-8-4-3-5-9-18)38-27(45)23(30)17(2)40;3-2(4,5)1(6)7/h3-5,8-9,16-17,19-21,23,40H,6-7,10-15,30H2,1-2H3,(H2,31,42)(H,35,43)(H,36,41)(H,37,44)(H,38,45)(H4,32,33,34);(H,6,7)/t16-,17+,19-,20-,21-,23-;/m0./s1
• InChIKey: APYDYKYMTBBPKU-CCCCMXJKSA-N
• SMILES: C[C@H]([C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(=O)N[C@@H](C)C(=O)N2CCC[C@H]2C(=O)N)N)O.C(=O)(C(F)(F)F)O

Protease-Activated Receptor-3 (PAR-3) (1–6), human TFA（Cat No.:I044269）is a synthetic peptide representing the N-terminal activation sequence of the human PAR-3 receptor. This receptor is part of the G-protein-coupled receptor (GPCR) family, activated by proteolytic cleavage that reveals a tethered ligand initiating intracellular signaling. The (1–6) fragment—typically the sequence TFRGAP—mimics the exposed ligand and is used to study PAR-3 activation mechanisms. The TFA (trifluoroacetate) salt form enhances peptide stability and handling. This peptide is valuable for exploring PAR-3’s roles in thrombosis, inflammation, and vascular biology.