For research use only. Not for therapeutic Use.
Protease-Activated Receptor-1 (PAR-1) Agonist（Cat No.:I044271）is a synthetic peptide that replicates the tethered ligand domain of PAR-1, a G-protein-coupled receptor activated by thrombin cleavage. By mimicking this activation sequence, the agonist peptide stimulates PAR-1 without the need for enzymatic cleavage, allowing precise control in experimental models. It is extensively used to study PAR-1-mediated signaling pathways involved in platelet activation, inflammation, endothelial function, and cancer progression. This tool is crucial for dissecting thrombin-independent receptor functions and evaluating potential therapeutic targets in cardiovascular and inflammatory diseases.
| CAS Number | 141136-85-8 |
| Synonyms | (2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-4-oxobutanoic acid |
| Molecular Formula | C35H58N10O9 |
| Purity | ≥95% |
| IUPAC Name | (2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-4-oxobutanoic acid |
| InChI | InChI=1S/C35H58N10O9/c1-18(2)14-23(30(49)41-22(12-9-13-40-35(38)39)29(48)45-26(34(53)54)17-27(36)47)42-31(50)24(15-19(3)4)43-32(51)25(16-21-10-7-6-8-11-21)44-33(52)28(37)20(5)46/h6-8,10-11,18-20,22-26,28,46H,9,12-17,37H2,1-5H3,(H2,36,47)(H,41,49)(H,42,50)(H,43,51)(H,44,52)(H,45,48)(H,53,54)(H4,38,39,40)/t20-,22+,23+,24+,25+,26+,28+/m1/s1 |
| InChIKey | HIKQWJFKUWYBNJ-GSAYKZDLSA-N |
| SMILES | C[C@H]([C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(=O)N)C(=O)O)N)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
