For research use only. Not for therapeutic Use.
PROTAC TTK Degrader-1（Cat No.:I043905）is a targeted protein degrader designed to selectively degrade TTK (MPS1), a critical kinase involved in cell division and tumor progression. By recruiting E3 ligases to TTK, this PROTAC facilitates its ubiquitination and subsequent proteasomal degradation, effectively reducing TTK levels in cancer cells. This selective degradation of TTK disrupts the mitotic checkpoint, leading to cell cycle arrest and potential cancer cell death. PROTAC TTK Degrader-1 holds promise as a novel therapeutic approach for the treatment of various cancers, particularly those with dysregulated mitotic processes.
| CAS Number | 2953426-43-0 |
| Synonyms | N-[4-[2-[4-[4-[6-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]hex-5-ynoyl]piperazin-1-yl]-2-methoxyanilino]-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8-yl]cyclohexyl]propanamide |
| Molecular Formula | C47H53N9O7 |
| Purity | ≥95% |
| IUPAC Name | N-[4-[2-[4-[4-[6-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]hex-5-ynoyl]piperazin-1-yl]-2-methoxyanilino]-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8-yl]cyclohexyl]propanamide |
| InChI | InChI=1S/C47H53N9O7/c1-4-40(57)49-32-11-13-33(14-12-32)56-43(60)24-29(2)36-27-48-47(52-44(36)56)50-37-17-15-34(26-39(37)63-3)53-20-22-54(23-21-53)42(59)9-7-5-6-8-30-10-16-35-31(25-30)28-55(46(35)62)38-18-19-41(58)51-45(38)61/h10,15-17,24-27,32-33,38H,4-5,7,9,11-14,18-23,28H2,1-3H3,(H,49,57)(H,48,50,52)(H,51,58,61) |
| InChIKey | LWHJKWAUKAHIGC-UHFFFAOYSA-N |
| SMILES | CCC(=O)NC1CCC(CC1)N2C(=O)C=C(C3=CN=C(N=C32)NC4=C(C=C(C=C4)N5CCN(CC5)C(=O)CCCC#CC6=CC7=C(C=C6)C(=O)N(C7)C8CCC(=O)NC8=O)OC)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
