PROTAC PD-1/PD-L1 degrader-1

• CAT Number: I015140
• CAS Number: 2447066-37-5
• Molecular Formula: C59H58ClN7O11
• Molecular Weight: 1076.59
• Purity: ≥95%
• Synonyms: 5-[4-[1-[[5-chloro-2-[(3-cyanophenyl)methoxy]-4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy]phenyl]methyl]piperidine-2-carbonyl]piperazin-1-yl]-N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]-5-oxopentanamide
• InChI: InChI=1S/C59H58ClN7O11/c1-36-40(10-5-11-42(36)39-17-19-48-51(30-39)76-27-26-75-48)35-78-50-31-49(77-34-38-9-4-8-37(28-38)32-61)41(29-44(50)60)33-66-21-3-2-14-47(66)58(73)65-24-22-64(23-25-65)54(70)16-7-15-52(68)62-45-13-6-12-43-55(45)59(74)67(57(43)72)46-18-20-53(69)63-56(46)71/h4-6,8-13,17,19,28-31,46-47H,2-3,7,14-16,18,20-27,33-35H2,1H3,(H,62,68)(H,63,69,71)
• InChIKey: CJIXMPCTSMEQPG-UHFFFAOYSA-N
• SMILES: CC1=C(C=CC=C1C2=CC3=C(C=C2)OCCO3)COC4=C(C=C(C(=C4)OCC5=CC(=CC=C5)C#N)CN6CCCCC6C(=O)N7CCN(CC7)C(=O)CCCC(=O)NC8=CC=CC9=C8C(=O)N(C9=O)C1CCC(=O)NC1=O)Cl

PROTAC PD-1/PD-L1 degrader-1（Cat No.:I015140）is a bifunctional small molecule designed to induce targeted degradation of the immune checkpoint proteins PD-1 or PD-L1. By hijacking the ubiquitin-proteasome system, it promotes selective elimination of these inhibitory receptors, thereby enhancing T-cell activation and antitumor immune responses. This degrader represents an advanced tool for studying immune checkpoint regulation and developing next-generation immunotherapies beyond monoclonal antibodies. It is particularly useful in cancer immunology research, offering insights into checkpoint blockade, tumor immune evasion, and therapeutic strategies for restoring immune surveillance.