For research use only. Not for therapeutic Use.
PROTAC KRAS G12C degrader-1（Cat No.:I044438）is a bifunctional molecule engineered to selectively degrade the KRAS G12C mutant protein, a key oncogenic driver in several cancers, including non-small cell lung and colorectal cancers. It combines a covalent KRAS G12C-binding ligand with an E3 ligase recruiter, facilitating ubiquitination and subsequent proteasomal degradation of the mutant protein. Unlike traditional inhibitors that block KRAS activity, this PROTAC eliminates the protein entirely, potentially overcoming resistance mechanisms. It is a valuable tool in precision oncology research, supporting the development of targeted degradation strategies for RAS-driven malignancies.
| CAS Number | 2984236-79-3 |
| Synonyms | 4-[12-[[6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(4-prop-2-enoylpiperazin-1-yl)quinazolin-2-yl]amino]dodecylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione |
| Molecular Formula | C50H54ClFN8O6 |
| Purity | ≥95% |
| IUPAC Name | 4-[12-[[6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(4-prop-2-enoylpiperazin-1-yl)quinazolin-2-yl]amino]dodecylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione |
| InChI | InChI=1S/C50H54ClFN8O6/c1-2-41(63)58-24-26-59(27-25-58)46-36-30-37(51)42(35-29-32(61)28-31-16-11-12-17-33(31)35)44(52)45(36)56-50(57-46)54-23-14-10-8-6-4-3-5-7-9-13-22-53-38-19-15-18-34-43(38)49(66)60(48(34)65)39-20-21-40(62)55-47(39)64/h2,11-12,15-19,28-30,39,53,61H,1,3-10,13-14,20-27H2,(H,54,56,57)(H,55,62,64) |
| InChIKey | FMYAMLPDKZOVMB-UHFFFAOYSA-N |
| SMILES | C=CC(=O)N1CCN(CC1)C2=NC(=NC3=C(C(=C(C=C32)Cl)C4=CC(=CC5=CC=CC=C54)O)F)NCCCCCCCCCCCCNC6=CC=CC7=C6C(=O)N(C7=O)C8CCC(=O)NC8=O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
