PROTAC IRAK4 degrader-1

• CAT Number: I017053
• CAS Number: 2360533-90-8
• Molecular Formula: C44H39F3N12O7
• Molecular Weight: 904.85
• Purity: ≥95%
• Synonyms: 2-[2-(cyclopropylmethylamino)pyridin-4-yl]-N-[1-[4-[3-[4-[[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]methyl]imidazol-1-yl]propylcarbamoyl]phenyl]-3-(trifluoromethyl)pyrazol-4-yl]-1,3-oxazole-4-carboxamide
• InChI: InChI=1S/C44H39F3N12O7/c45-44(46,47)37-31(53-39(62)32-22-66-41(54-32)26-13-15-48-34(17-26)51-18-24-5-6-24)21-58(56-37)28-9-7-25(8-10-28)38(61)49-14-2-16-57-20-27(52-23-57)19-50-30-4-1-3-29-36(30)43(65)59(42(29)64)33-11-12-35(60)55-40(33)63/h1,3-4,7-10,13,15,17,20-24,33,50H,2,5-6,11-12,14,16,18-19H2,(H,48,51)(H,49,61)(H,53,62)(H,55,60,63)
• InChIKey: YXSXFMHKDNIZFS-UHFFFAOYSA-N
• SMILES: C1CC1CNC2=NC=CC(=C2)C3=NC(=CO3)C(=O)NC4=CN(N=C4C(F)(F)F)C5=CC=C(C=C5)C(=O)NCCCN6C=C(N=C6)CNC7=CC=CC8=C7C(=O)N(C8=O)C9CCC(=O)NC9=O

PROTAC IRAK4 degrader-1(CAT: I017053) is a bifunctional small molecule designed to induce targeted degradation of interleukin-1 receptor–associated kinase 4 (IRAK4), a critical mediator in innate immune and inflammatory signaling. Built on the PROTAC strategy, it links an IRAK4-binding ligand to an E3 ligase recruiter, promoting ubiquitination and proteasomal degradation of IRAK4. This compound effectively suppresses downstream signaling pathways, including NF-κB and MAPK activation, making it a valuable probe for studying IRAK4-dependent biology. PROTAC IRAK4 degrader-1 holds promise for therapeutic exploration in autoimmune disease, inflammatory disorders, and oncology, where aberrant IRAK4 signaling contributes to disease progression.