PROTAC EGFR degrader 3

• CAT Number: I043883
• CAS Number: 2768472-28-0
• Molecular Formula: C60H77N13O5S
• Molecular Weight: 1092.40
• Purity: ≥95%
• Synonyms: (2S,4R)-1-[(2S)-2-[8-[4-[4-[[8-anilino-9-[(3S)-1-prop-2-enoylpiperidin-3-yl]purin-2-yl]amino]phenyl]piperazin-1-yl]octanoylamino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide
• InChI: InChI=1S/C60H77N13O5S/c1-7-52(76)71-30-16-19-47(37-71)73-55-49(66-59(73)65-44-17-12-11-13-18-44)36-61-58(68-55)64-45-25-27-46(28-26-45)70-33-31-69(32-34-70)29-15-10-8-9-14-20-51(75)67-54(60(4,5)6)57(78)72-38-48(74)35-50(72)56(77)63-40(2)42-21-23-43(24-22-42)53-41(3)62-39-79-53/h7,11-13,17-18,21-28,36,39-40,47-48,50,54,74H,1,8-10,14-16,19-20,29-35,37-38H2,2-6H3,(H,63,77)(H,65,66)(H,67,75)(H,61,64,68)/t40-,47-,48+,50-,54+/m0/s1
• InChIKey: RYXQXEGTLNBKEC-DKQRTKIFSA-N
• SMILES: CC1=C(SC=N1)C2=CC=C(C=C2)[C@H](C)NC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)CCCCCCCN4CCN(CC4)C5=CC=C(C=C5)NC6=NC=C7C(=N6)N(C(=N7)NC8=CC=CC=C8)[C@H]9CCCN(C9)C(=O)C=C)O

PROTAC EGFR Degrader 3（Cat No.:I043883）is a targeted protein degrader designed to selectively degrade epidermal growth factor receptor (EGFR), a key driver of tumor growth in several cancers, including non-small cell lung cancer. By utilizing the PROTAC technology, it recruits an E3 ligase to induce the ubiquitination and subsequent proteasomal degradation of EGFR. This mechanism leads to the downregulation of EGFR signaling, which is critical for cancer cell survival and proliferation. PROTAC EGFR Degrader 3 represents a promising therapeutic strategy for cancers resistant to conventional EGFR-targeted therapies.