PROTAC eDHFR Degrader-1

• CAT Number: I040604
• CAS Number: 2849442-92-6
• Molecular Formula: C36H44N8O10
• Molecular Weight: 748.78
• Purity: ≥95%
• Synonyms: 4-[4-[(2,4-diaminopyrimidin-5-yl)methyl]-2,6-dimethoxyphenoxy]-N-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethyl]butanamide
• InChI: InChI=1S/C36H44N8O10/c1-50-26-18-21(17-22-20-41-36(38)43-32(22)37)19-27(51-2)31(26)54-12-4-7-28(45)40-11-14-53-16-15-52-13-10-39-24-6-3-5-23-30(24)35(49)44(34(23)48)25-8-9-29(46)42-33(25)47/h3,5-6,18-20,25,39H,4,7-17H2,1-2H3,(H,40,45)(H,42,46,47)(H4,37,38,41,43)
• InChIKey: PJVJIKUHLULMOV-UHFFFAOYSA-N
• SMILES: COC1=CC(=CC(=C1OCCCC(=O)NCCOCCOCCNC2=CC=CC3=C2C(=O)N(C3=O)C4CCC(=O)NC4=O)OC)CC5=CN=C(N=C5N)N

PROTAC eDHFR Degrader-1(CAT: I040604) is a heterobifunctional molecule engineered to induce targeted degradation of Escherichia coli dihydrofolate reductase (eDHFR)-tagged fusion proteins. It consists of an eDHFR ligand linked to an E3 ligase recruiter, promoting ubiquitination and proteasomal degradation of eDHFR-tagged targets in cells. This tool is ideal for validating PROTAC mechanisms, studying protein function with temporal control, and optimizing degrader design. It enables rapid and reversible protein knockdown in synthetic biology and cell signaling applications. PROTAC eDHFR Degrader-1 is widely used in research involving protein engineering, degradation platforms, and the development of inducible degradation systems in mammalian cells.