PROTAC CDK9 ligand-1

• CAT Number: I045567
• CAS Number: 3031327-95-1
• Molecular Formula: C20H28N6O
• Molecular Weight: 368.48
• Purity: ≥95%
• Synonyms: (2S)-2-[[7-[(4-aminophenyl)methylamino]-3-propan-2-ylpyrazolo[1,5-a]pyrimidin-5-yl]amino]butan-1-ol
• InChI: InChI=1S/C20H28N6O/c1-4-16(12-27)24-18-9-19(22-10-14-5-7-15(21)8-6-14)26-20(25-18)17(11-23-26)13(2)3/h5-9,11,13,16,22,27H,4,10,12,21H2,1-3H3,(H,24,25)/t16-/m0/s1
• InChIKey: ZTQFEMJXWCDAAJ-INIZCTEOSA-N
• SMILES: CCC(CO)NC1=NC2=C(C=NN2C(=C1)NCC3=CC=C(C=C3)N)C(C)C

PROTAC CDK9 ligand-1 (Cat No.: I045567) is a small-molecule ligand component designed for the construction of proteolysis-targeting chimeras (PROTACs) that induce selective degradation of cyclin-dependent kinase 9 (CDK9). By recruiting CDK9 to an E3 ubiquitin ligase, PROTACs built with this ligand promote ubiquitination and proteasomal degradation, suppressing CDK9-dependent transcriptional programs. This compound is widely used in chemical biology and oncology research to investigate transcriptional regulation, cancer progression, and targeted protein degradation strategies, making it a valuable tool for drug discovery and epigenetic studies.

Reference

[1]. Wei D, et al. Discovery of Potent and Selective CDK9 Degraders for Targeting Transcription Regulation in Triple-Negative Breast Cancer. J Med Chem. 2021 Oct 14;64(19):14822-14847.
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