For research use only. Not for therapeutic Use.
PROTAC CBP/p300 Degrader-1（Cat No.:I044621）is a bifunctional molecule designed to selectively degrade the transcriptional coactivators CBP and p300 via the proteolysis targeting chimera (PROTAC) mechanism. It links a high-affinity CBP/p300-binding moiety to an E3 ligase recruiter, inducing ubiquitination and proteasomal degradation of CBP/p300. These coactivators are key regulators of histone acetylation and gene transcription, often implicated in cancer and inflammatory diseases. PROTAC CBP/p300 Degrader-1 enables precise modulation of epigenetic control and transcriptional activity, making it a powerful research tool for studying gene regulation and advancing targeted protein degradation therapies.
| CAS Number | 2484739-48-0 |
| Synonyms | 3-[7-(difluoromethyl)-6-(1-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-1-[1-[6-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]hexanoyl]piperidin-4-yl]-N-methyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carboxamide |
| Molecular Formula | C46H53F2N11O6 |
| Purity | ≥95% |
| IUPAC Name | 3-[7-(difluoromethyl)-6-(1-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-1-[1-[6-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]hexanoyl]piperidin-4-yl]-N-methyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carboxamide |
| InChI | InChI=1S/C46H53F2N11O6/c1-49-46(65)56-21-16-35-33(26-56)42(57-18-7-8-27-22-31(28-24-51-54(2)25-28)32(41(47)48)23-37(27)57)53-59(35)29-14-19-55(20-15-29)39(61)11-4-3-5-17-50-34-10-6-9-30-40(34)45(64)58(44(30)63)36-12-13-38(60)52-43(36)62/h6,9-10,22-25,29,36,41,50H,3-5,7-8,11-21,26H2,1-2H3,(H,49,65)(H,52,60,62) |
| InChIKey | KOXRGDZBEAJAKE-UHFFFAOYSA-N |
| SMILES | CNC(=O)N1CCC2=C(C1)C(=NN2C3CCN(CC3)C(=O)CCCCCNC4=CC=CC5=C4C(=O)N(C5=O)C6CCC(=O)NC6=O)N7CCCC8=CC(=C(C=C87)C(F)F)C9=CN(N=C9)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
